Our research aims at investigating the molecular basis of autism, a brain disorder of proven neurodevelopmental origin whose cellular and molecular causes remain largely unknown. We use a multidisciplinary approach, ranging from neuroanatomical to behavioral studies, to identify autistic-like deficits in monogenic mouse models.
- Developmental bases of autism. We study how mutations in neural genes during embryonic brain development can impact autistic-like behaviors during postnatal life. We extensively studied mice lacking the homeobox-containing gene Engrailed-2 (En2-/- mice), showing that these mice have anatomical and molecular defects of GABAergic interneurons, leading to impaired social and cognitive behaviors. Our current research aims to identify the behavioural outcomes of GABAergic neuron dysfunction in other monogenic mouse models of autism.
Our research group is currently located at the Centre for Integrative Biology of the University of Trento.
- Yuri Bozzi PhD, PI
- Silvia Bronzoni, research assistant
- Francesco Libera, student
For a complete list: http://webapps.unitn.it/Ugcvp/it/Web/ProdottiAutore/PER0038950
- 2018-2020: University of Trento Strategic Project TRAIN – Trentino Autism Initiative. PI Yuri Bozzi
- Giovanni Provenzano, Centre for Integrative Biology (CIBIO), University of Trento, Italy
- Simona Casarosa, Centre for Integrative Biology (CIBIO), University of Trento, Italy
- Alessandro Gozzi, IIT Italian Institute of Technology, Rovereto, Italy
- Valerio Zerbi, ETH Zurich, Switzerland
- Antonello Mallamaci, SISSA, Trieste, Italy